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Dienstag, 6. November 2018 10:27:06

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The impact of assay conditions on IC50 determination is negligible, kinetic characteristics differ among used test substrates, and substrate-dependent inhibition exists for MATE1 and MATE2-K , giving valuable insight into the assessment of clinically relevant MATE-mediated drug interactions in vitro. We suggest that the detailed analysis of MATE1 expression levels and mutations could be a predictor for the response to imatinib therapy. MATE1 mRNA levels in peripheral blood cells were significantly higher in patients carrying the minor allele of rs, but not rs, compared to those with other genotypes.

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Shao, Li, Feng, Lin, Billig: Direct effects of metformin in the endometrium:

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